Keep an eye on Closely (one)mitotane decreases levels of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is actually a strong inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for probable dosage changes.glucagon increases toxicity of scopolamine by Other (see